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By directly comparing the immune cells of healthy controls with those of ME/CFS and Long COVID patients, the study proved that severe oxidative stress is a shared, defining characteristic of both conditions

Romieu I., Dossus L., Barquera S., Blottire H.M., Franks P.W., Gunter M., Hwalla N., Hursting S.D., Leitzmann M., et al

In addition to limited absorption via the IF, the intake of high-dose supplements leads to passive diffusion, i.e., the vitamin can freely enter the bloodstream without IF binding and receptor uptake

If it cant protect it, then B12 gets damaged, and it cant activate the cells as it should

Examples of these health conditions include those with a lack of stomach acid, those who have undergone bariatric surgery, anemia caused by the inability to absorb the vitamin, other autoimmune digestive diseases, as well as several medications