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8 Discussion The present work sheds light on the possible metabolic factors playing a role in vitiligo pathogenesis, both at a cellular and a systemic level

We found that LTR had significantly higher levels of three amino acids known to increase mTOR activity in T cells (asparagine, alanine, and arginine) 14 , suggesting an extrinsic microenvironmental contribution to the increased mTOR activity seen in the CAR T cells of this cohort (Fig

Any weight change is likely due to other factors

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In fact, an increase in the permeability of the intestine due to changes in the functioning and/or in the expression levels of the TJ proteins cause leaky gut syndrome or LGS