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Colostrum levels were 778 and 320 pmol/L (1,054 and 434 ng/L), respectively, and at 3 months postpartum were 235 and 170 pmol/L (318 and 230 ng/L), respectively.[25] Based on the 65 pmol/L (88 ng/L) difference in median milk levels reported at 3 months, exclusively breastfed infants would receive an extra 0.013 mcg/kg daily of vitamin B 12 from maternal 250 mcg once daily oral supplementation

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[11] [9] This explains why therapeutic doses are substantially higher than dietary requirements

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However, two other forms hydroxocobalamin and cyanocobalamin become biologically active after they are converted to methylcobalamin or 5-deoxy adenosylcobalamin, said Dr Aravinda G M, consultant, internal medicine, Manipal Hospital, Jayanagar, Bangalore

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