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When this occurs there are a number of side effects to be aware of

Corticosteroids may activate latent amebiasis

Importantly, while folic acid successfully decreases these toxicities, it does not alter or compromise the clinical efficacy of low-dose methotrexate in controlling joint inflammation and disease activity parameters (Friedman & Cronstein, 2019)

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While this can be due to several factors, including magnesium deficiency, several studies highlight the important influence of glutathione (GSH) levels on vitamin D status and activity