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There is a correlation between TLR4 activation and CP-induced neurotoxicity, as well as the following surplus output of pro-inflammatory cytokines and their important role in the pathophysiology of the cognitive impairment that is associated with this condition, according to a study that was conducted not too long ago (Ren et al

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This work was supported by the Department of Defense Peer Reviewed Medical Research Program grant PR141776 (S.J.W.), University of Texas Medical Branch Technology Commercialization Award (S.J.W), and NIH grant R01GM112936 (C.C.F)