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Interestingly, Nrf2 expression is significantly downregulated in peritoneal tissue-resident macrophages isolated from Immune-responsive gene 1 ( Irg1 ) shRNA-injected tumor-bearing mouse (79)

75 Food and Agriculture Organization of the United Nations (2022)

doi: 10.1101/cshperspect.a020412 48

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These implied that polysaccharides may activate numerous different cell death forms through initial modulation of lipid peroxidation to collateral regulation of signaling pathways, thereby controlling the decision to die