An intriguing aspect of biogenesis is its regulatory crosstalk with other epitranscriptomic marks
When aluminum is above about 1.2 mg% or manganese is greater than about 0.04 mg% in the hair tissue, iron toxicity with biounavailable iron is almost always present
However, most of these studies were retrospective and non-randomized
Food Sci Biotechnol 27:219225 Jikihara H, Qi G, Nozoe K et al (2015) Aged garlic extract inhibits 1, 2-dimethylhydrazine-induced colon tumor development by suppressing cell proliferation
To confirm these results, the authors proposed to engineer the CHO host cell line to eliminate the endogenous expression of LPLA2 and to repeat the formulation experiments to determine whether they are stabilised, i.e., reduced polysorbate hydrolysis, using the LPLA2 knockout approach (Hall et al., 2016)