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The vast majority of the positive studies were conducted by Melinda Connor and Caitlin Connor, and the papers they produced are of shockingly bad quality

Preclinical studies have described the role of Vitamin E in AD: it seems to reduce transepidermal water loss (TEWL), which is associated with AD pathogenesis, and to induce the expression of the transglutaminase-1 gene, involved in terminal differentiation of keratinocytes and in the formation of the stratum corneum (8385)

This enzyme catalyses the transfer of the -glutamyl moiety of GSH to another amino acid to produce a -Glu-AA and cysteinyl-glycine

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This dimeric form of Prx2 is non-functional, but the disulfide bridge between the subunits can be broken by Trx, regenerating Prx2, and completing the catalytic cycle [73]