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Taken together, our finding provides new insight into the role of epigenetic modification in self-RNA/TLR7 pathway-dependent immune cell activation and chemotaxis during psoriasis, which proposes the promising therapeutic strategy to control the inflammatory damage and psoriatic skin dysfunction by targeting KAT8 and KAT8-mediated H4K16ac modification in dermis macrophages

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Natural Killer (NK) cells are a critical component of the innate immune system, responsible for identifying and destroying virally infected cells and early-stage malignancies