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Reprod BioMed Online (2013) 26(1):6878

These non-motor symptoms can include olfactory impairment, sleep disturbances, constipation, mood changes, and other subtle changes that can occur years before the appearance of motor symptoms

The results showed that the mice that experienced hypoxia for 14 days still had obvious cognitive-behavioral impairment after reoxygenation for 28 days, suggesting that the neurological damage induced by chronic hypoxia was irreversible (Fig