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It is naturally synthesized by every cell in the body, with particularly elevated concentrations found in the liver

Nitrofurantoin is a prodrug that is activated by cellular nitroreductases leading to the formation of reactive species that damage cellular macromolecules, most prominently DNA, causing nucleoid relaxation and, at high doses, destruction of the entire nucleoid

84 Nevertheless, the results from the studies are conflicting, and sufficiently large genomic studies are needed to further develop the understanding

Every year, thousands of people (children and adults) are injured, and hundreds die from taking too much of the easy-to-obtain OTC medication used to reduce pain named acetaminophen (initially marketed in 1959 under the brand name Tylenol)

Neurosci Lett 806: 137236, 2023