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It works by inhibiting the NNMT enzyme, which is associated with fat storage, insulin resistance, and reduced cellular energy

But the AOD 9604 and tirzepatide stack attacks the problem from two entirely different directions, creating what some clinicians describe as a synergistic metabolic advantage that neither compound achieves alone

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Johnson, M., & Lee, A

While the theoretical synergy of boosting cellular health (NAD+) while simultaneously optimizing metabolic fat regulation (AOD9604) is appealing, robust scientific evidence for their combined use is still in its nascent stages