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In contrast, the exposed rats exhibited changes in the form of inflammatory cell infiltrate, and the remaining exposed rats displayed a liver morphology within normal limits (Table 1)

The gut microbiota regulates the metabolism and side effects of irinotecan (CPT-11), a topoisomerase inhibitor prodrug of SN-38 that is frequently used to treat colorectal cancer (Wallace et al., 2018)

10.1016/j.rbp.2011.12.001 Braz J Psychiatry

Tumors and major organs, including heart, liver, spleen, lung, and kidney were isolated for pathological section analyses

However, if polymorphisms in the glucoronosyI transferases reduce the V max values to 50% of normal then the number of hepatocytes drops to about 75% of normal after 20 hours