In gastric and colorectal cancer, high CHAC2 expression leads to reduced glutathione, elevated intracellular Ca 2+ and increased ROS, resulting in inhibited tumor growth, proliferation and migration
Thus, having the alleles GCLC rs1555903-C and GCLM rs41303970-C drives to more glutathione production, which could be efficiently conjugated to Hg by members of the GST-superfamily such GSTP1the most widely expressed GST enzyme according to the Human Protein Atlas 37 , including in the kidneys
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Extracting peptides while removing interfering substances is essential for accurate detection
After taking blood samples from the patients, they were informed and we obtained their consent to conduct this research