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Smoking the primary cause of COPD Prolonged exposure to environmental irritants (toxic fumes, dust, air pollution, secondhand smoke, etc.) History of serious childhood respiratory infections such as pneumonia Gastroesophageal reflux disease (GERD) may cause or worsen COPD Genetics deficiency of alpha-1 antitrypsin (AAT), a protein produced in the liver Symptoms of COPD include chronic cough or cough with large amounts of mucus, shortness of breath that worsens with exertion, wheezing and tightness in the chest, fatigue, and low oxygen blood saturation

Contributions to Tobacco & Nicotine Research, 21(4), 2013-0781 Tadsanaprasittipol, A., Tonrub, P., Beverland, I.J