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157 We posit that for high affinity metals, notably Cu II (and Cu I ), Zn II and Ni II , affinities are so tight so as to render metal dissociation rates (off-rates), even if increased by the presence of metal-buffering small molecules, far too slow to be relevant during intermolecular metal transfer (Figure 34, top )

Loren Pickart, who identified the copper-binding tripeptide while studying why blood plasma from younger donors was more effective than plasma from older donors at supporting liver cell function in a study comparing donors ages 2025 to donors ages 6080

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