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The potency of Nicotiana rustica , a strong tobacco species commonly used by Native Americans, was far greater than that of Nicotiana tabacum , the species later favored in European cultivation

In the smoking process, nicotine would degrade into nitrogen heterocyclic aromatic components, such as pyrrole, pyridine, and pyrazine compounds, which endows the CTLs with fragrant baked and caramel aromas 23

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