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Depression is an inflammatory disorder and it is known that IL-23 and IL-17 are important in inducing central nervous system inflammation

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This includes increased phosphorylation of dynamin-related protein 1 (DRP1) at serine-616, promoting mitochondrial fragmentation, and decreased expression of fusion proteins such as mitofusins (MFN1/2) and optic atrophy 1 (OPA1) (Vaccaro et al., 2020

It involves the administration of glutathione either through oral supplements, intravenous injections, or topical creams

Plant Biol 27(1):317 Livrea MA, Tesoriere L, Tan DX, Reiter RJ (2001) Radical and reactive intermediate-scavenging properties of melatonin in pure chemical systems