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27 investigated five patients with clEDS and histological investigations reported gross abnormalities of the elastic fibers and microfibrils in the dermis of these patients and reduced dermal collagen content

doi: 10.1074/jbc.M209715200 199

doi:10.3109/10715762.2010.485989 Diaz Vivancos P, Wolff T, Markovic J, Pallard FV, Foyer CH (2010) A nuclear glutathione cycle within the cell cycle

Occasionally, minor sensations of pressure or slight discomfort at the insertion site can occur, but these typically subside shortly after treatment begins