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Mediation was assessed separately for each outcome using the Karlson-Holm-Breen (KHB) method that extends the linear regression framework to the ordinal logistic regression framework 30

The idea originated during the first Trump administration and then pushed again by the Biden administration and anti-smoking advocates who want to limit nicotine in cigarettes and other combustible tobacco products to make them less addictive and easier to quit

The vertical back print changes how the design interacts with the body, creating a different visual flow

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