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Since the list of contraindications of Vit B12 is really restrained to Leber optic neuropathy as it may aggravate it and to advanced renal failure since the injections may include aluminum in its components, we may suggest to consider systematically supplementing PD patients with B12 in the absence of contraindications or potential adverse effects (McCarter et al

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Its important to note that the timeline for experiencing the benefits of B12 shots may vary depending on the severity of your deficiency