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Schwalfenberg, 2021), sex, low intracellular GSH, cigarette smoking and presence of chronic diseases, among other factors, and GSH deficiency caused by any or all these factors may contribute to severe COVID-19 disease pathogenesis (Polonikov, 2020

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The double-blind study used an innovative strategy of including multi-modal measures of target engagement, including kappa opiate receptor occupancy, functional MRI and transcranial magnetic stimulation measure of cortical inhibition

As research progresses, new therapeutic approaches might emerge

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