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O'Neill in 1962 to measure the heat flow of solid materials and determine phase transitions, melting, crystallization, and heat capacity (Watson and O'Neill, 1962), whereas in 1964, Peter L

Its design illustrates a radical peptidomimetic : only two amino acid residues (Tyr-Ile) are preserved from the native peptide, flanked by non-peptide acyl chains to cross biological barriers

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