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By the physicians of Amanecia Health | Updated April 27, 2026 Last reviewed June 18, 2026 by Ann Czarnik, M.D., FACEP

A consistent pattern emerges: evidence is mostly limited to animal studies human studies, where they exist, are small and short-term there are no high-quality trials reflecting real-world use, including combinations, higher doses or long-term administration

It can be difficult to consistently obtain all necessary nutrients through diet alone

10.1097/00008571-200211000-00002 72 KhouryM