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For in vivo animal models, dosage is adjusted based on species and study specifics

In the pathology of RA, IL-6 can stimulate pannus formation through increased vascular endothelial growth factor expression and increase bone resorption as a result of osteoclastogenesis, as well as oxidative stress in leukocytes

doi: 10.1186/s41073-019-0064-8, 34

Complete blood cell counts remained within normal limits for all samples taken on days 0, 7, and 14, suggesting that topical applications of TCC and zinc oxide did not result in systemic abnormalities

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